Soma Carisoprodol News Blog

In an attempt to determine the mechanism of action of carisoprodol (Soma) in the treatment of low back pain, a double blind study was carried out comparing its effectiveness to that of a sedative control, butabarbital (a sedative), and a placebo in the treatment of 48 laborers with acute lumbar pain. The results of the study have shown that carisoprodol is significantly more effective than butabarbital or placebo in providing both subjective pain relief and objective improvements in range of motion when evaluated by finger to floor testing (4). The results of the study suggests that effects of carisoprodol are not due solely to sedative action, but are also related to its muscle relaxant activity.

In a double-blind study carisoprodol was found to be superior to diazepam in the treatment of patients with at least moderately severe low back pain and spasm of no longer than seven days duration.

The first RCT (80 people) found that carisoprodol significantly increased overall improvement compared with diazepam but found no significant difference in pain at 7 days (improvement rated as very good or excellent; 70% with carisoprodol v 45% with diazepam; pain on 100 mm visual analogue scale: 58 mm with carisoprodol v 48 mm with diazepam; P values not reported in the review)

Carisoprodol was more effective than diazepam in overall relief of acute LBP (70% vs. 45%)

In this head-to-head trial, the overall incidence of adverse reactions was higher in the diazepam treated group but was not of statistical significance.

In a trial of cyclobenzaprine versus carisoprodol in patients with acute back pain and spasms there were no significant differences for pain, muscle stiffness, activity impairment, sleep impairment, tension, or relief scores compared to baseline. In this head-to-head trial dry mouth was more frequent with cyclobenzaprine (38% vs. 10%) and dizziness less frequent (8% vs. 26%). Withdrawal rates due to adverse events were equal (8%) (3).

The European Medicines Agency (EMEA) has recommended the suspension of marketing authorisations for all medicinal products containing carisoprodol. Carisoprodol products are available in 12 Member States under prescription, mainly for the treatment of acute lower back pain.

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Finalising its review, the Agency’s Committee for Medicinal Products for Human Use (CHMP) concluded that the risks of these medicines are greater than their benefits, and recommended the suspension of marketing authorisations in those Member States where the product is approved.

The review of carisoprodol-containing medicinal products was initiated in September 2007 following plans made for its withdrawal from the Norwegian market (scheduled to take effect as of May 2008), due to new information relating to an increased risk of abuse or addiction as well as intoxication and events related to psychomotor impairment. The CHMP reviewed the safety of these medicines to assess whether the regulatory actions taken by Norway should be implemented throughout the EU countries.

Following the assessment of the available information on the safety of carisoprodol-containing medicinal products, the CHMP concluded that there is evidence for carisoprodol-associated risk of abuse and addiction, intoxication and psychomotor impairment. In the light of these findings the CHMP considered that the risks of these medicines outweigh their benefits. The CHMP therefore recommended the suspension of the marketing authorisations of all carisoprodol-containing medicinal products.

Due to the risk of withdrawal symptoms, patients should not stop carisoprodol treatment before seeking advice from their doctor on other therapeutic options. Any switch to new medication should be made gradually and under medical supervision.

The CHMP opinion will now be sent to the European Commission for the adoption of a decision, applicable in all EU countries.

Notes:

1. More information about the review is available in a separate question-and-answer-document: click here.

2. Carisoprodol-containing medicinal products are available in Europe in the Czech Republic, Denmark, Finland, Greece, Hungary, Iceland, Italy, Norway, the Slovak Republic, Spain, Sweden and the United Kingdom.

3. Carisoprodol-containing medicinal products include Somadril, Somadril comp, Carisoma, Soma Complex, Scutamil C, Relacton-C, Mio Relax and Relaxibys.

4. The review of carisoprodol was conducted under Article 107 of the Community code relating to medicinal products for human use (Directive 2001/83/EC). This type of procedure is initiated in cases where a Member State withdraws, suspends or changes the marketing authorisation of a nationally authorised medicine as a result of the evaluation of safety data. It provides for a harmonised European approach because the CHMP is asked to prepare an opinion on whether or not the regulatory actions should be implemented throughout the European Union.

5. This press release, together with other information on the work of the EMEA, can be found on the EMEA website: http://www.emea.europa.eu

Carisoprodol is a centrally-acting skeletal muscle relaxant whose active metabolite is meprobamate. Although several case reports have shown that carisoprodol has abuse potential, it continues to be widely prescribed (except in the United Kingdom where use of benzodiazepines is preferred). Carisoprodol is a colourless, crystalline powder, having a mild, characteristic odor and a bitter taste. It is slightly soluble in water and freely soluble in alcohol, chloroform and acetone. Its solubility is practically independent of pH.

Carisoprodol is marketed in the United States under the brand name Soma, and in the United Kingdom and other countries under the brand names Sanoma and Carisoma. Carisoprodol is especially useful against various types of pain (whether or not related to muscle spasm) because of its analgesic-sparing (potentiating) effect on opioid analgesics. Carisoprodol is available by itself or mixed with aspirin and in one preparation (Soma Compound With Codeine®) along with codeine and caffeine as well.

As of November 2007 Carisoprodol has been taken off the market in Sweden due to problems with dependence, abuse and side effects. The agency overseeing pharmaceuticals has considered other drugs used with the same indications as carisoprodol to have the same or better effects without the risks of the drug.

Carisoprodol History

On June 1, 1959 several American pharmacologists convened at Wayne State University in Detroit, Michigan to discuss a new drug. The drug, originally thought to have antiseptic properties, was found to have central muscle relaxing properties. It had been developed by Dr. Frank M. Berger at Wallace laboratories and had been named carisoprodol (trade name Soma).

Carisoprodol was developed on the basis of meprobamate, in the hope that it would have better muscle relaxing properties, less potential for abuse, and less risk of overdose than meprobamate. The substitution of one hydrogen atom with an isopropyl group on one of the carbamyl nitrogens was intended to yield a molecule with new pharmacological properties.

The brand name Soma is shared with the fictional drug featured in Aldous Huxley’s Brave New World.

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Source: Carisoprodol from Wikipedia

So, you’re interested in buying Soma online. Purchasing meds online should not be a decision made lightly. Buying meds is not and should not be treated like buying a movie dvd at your nearest internet superstore.

The first and foremost step you should take is a complete medical examination by your personal physician to ensure the requested drug should be taken. If your medical professional recommends the taking of Soma or any other med you should feel free to seek out the best possible price.

Oftentimes, individuals with health insurance will still be able to find and buy soma online for a cheaper price then your local drugstore. When using the online pharmacy route to buy soma, caution should be of utmost importance. If you plan on purchasing soma or any other drug online you MUST qualify the online pharmacy prior to transacting. Visit as many pharmacies as possible to not only check pricing but also check origin of supply, test out customer service of pharmacy (does the pharmacy offer online chat, toll free numbers) and is return email requests replied within a timely manner?

Following these steps to prior to buying soma online will certainly save you money, and possible save your health. On a final note, please delete and stay away from pharmacy email spam as these “scmasters” are certainly out to rip you off and possibly steal your personal info (think identity theft).

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Generic Soma (Carisoprodol) relaxes muscles and relieves pain and discomfort associated with strains, sprains, spasms or other muscle injuries. Muscle relaxers are for specific muscle injury and pain and should not be used for general body aches and pains.

Generic Soma (Carisoprodol) may be taken with food or immediately after meals to prevent stomach upset. Take this as directed. Do not increase your dose or take it more often than prescribed. This medication provides temporary relief and must be used in addition to rest, physical therapy and other measures. Because this medication makes an injury temporarily feel better, do not attempt to lift or exercise too soon.

Before taking Generic Soma, you have to tell your doctor your medical history, especially of: any liver or kidney disease, blood disorders, porphyria, asthma, any allergies. When rising quickly from a sitting or lying position, dizziness or lightheadedness may occur. Change positions slowly. Use caution engaging in activities requiring alertness (such as driving) if this drug makes you dizzy or drowsy. Limit alcohol intake while taking this medication. This drug should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Carisoprodol is excreted into breast milk. Consult your doctor before breast-feeding.

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